Ontology highlight
ABSTRACT:
SUBMITTER: Friend K
PROVIDER: S-EPMC2149891 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Friend Kyle K Lovejoy Alexander F AF Steitz Joan A JA
Molecular cell 20071001 2
In metazoa, pre-mRNA 3' end formation occurs via two pathways: cleavage/polyadenylation for the majority of RNA polymerase II transcripts and U7-snRNP-dependent cleavage for replication-dependent histone pre-mRNAs. An RNA element derived from a replication-dependent histone gene affects multiple steps of pre-mRNA processing. Here, we demonstrate that a portion of this RNA element, present in the majority of histone mRNAs, stimulates U7-snRNP-dependent cleavage. Surprisingly, this element binds U ...[more]