Ontology highlight
ABSTRACT:
SUBMITTER: Yang XC
PROVIDER: S-EPMC3536302 | biostudies-other | 2013 Jan
REPOSITORIES: biostudies-other
Yang Xiao-Cui XC Sabath Ivan I Dębski Jan J Dębski Jan J Kaus-Drobek Magdalena M Dadlez Michał M Marzluff William F WF Dominski Zbigniew Z
Molecular and cellular biology 20121015 1
Animal replication-dependent histone pre-mRNAs are processed at the 3' end by endonucleolytic cleavage that is not followed by polyadenylation. The cleavage reaction is catalyzed by CPSF73 and depends on the U7 snRNP and its integral component, Lsm11. A critical role is also played by the 220-kDa protein FLASH, which interacts with Lsm11. Here we demonstrate that the N-terminal regions of these two proteins form a platform that tightly interacts with a unique combination of polyadenylation facto ...[more]