Ontology highlight
ABSTRACT:
SUBMITTER: Cau J
PROVIDER: S-EPMC2150914 | biostudies-literature | 2001 Dec
REPOSITORIES: biostudies-literature
The Journal of cell biology 20011201 6
Coordination of the different cytoskeleton networks in the cell is of central importance for morphogenesis, organelle transport, and motility. The Rho family proteins are well characterized for their effects on the actin cytoskeleton, but increasing evidence indicates that they may also control microtubule (MT) dynamics. Here, we demonstrate that a novel Cdc42/Rac effector, X-p21-activated kinase (PAK)5, colocalizes and binds to both the actin and MT networks and that its subcellular localizatio ...[more]