Structural and functional studies indicate that the EPEC effector, EspG, directly binds p21-activated kinase.

ABSTRACT: Bacterial pathogens secrete effectors into their hosts that subvert host defenses and redirect host processes. EspG is a type three secretion effector with a disputed function that is found in enteropathogenic Escherichia coli. Here we show that EspG is structurally similar to VirA, a Shigella virulence factor; EspG has a large, conserved pocket on its surface; EspG binds directly to the amino-terminal inhibitory domain of human p21-activated kinase (PAK); and mutations to conserved residues in the surface pocket disrupt the interaction with PAK.

SUBMITTER: Germane KL 

PROVIDER: S-EPMC3040069 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature