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A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus.

ABSTRACT: An S678P substitution in Fks1p, the major subunit of glucan synthase, was sufficient to confer echinocandin resistance in Aspergillus fumigatus. The equivalent mutation in Candida spp. has been implicated in echinocandin resistance. This work demonstrates that modification of Fks1p is a conserved mechanism for echinocandin resistance in pathogenic fungi.

SUBMITTER: Rocha EM 

PROVIDER: S-EPMC2151465 | biostudies-literature | 2007 Nov

REPOSITORIES: biostudies-literature

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A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus.

Rocha Eleusa Maria F EM   Garcia-Effron Guillermo G   Park Steven S   Perlin David S DS  

Antimicrobial agents and chemotherapy 20070827 11

An S678P substitution in Fks1p, the major subunit of glucan synthase, was sufficient to confer echinocandin resistance in Aspergillus fumigatus. The equivalent mutation in Candida spp. has been implicated in echinocandin resistance. This work demonstrates that modification of Fks1p is a conserved mechanism for echinocandin resistance in pathogenic fungi. ...[more]

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