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A Phe389Leu substitution in ergA confers terbinafine resistance in Aspergillus fumigatus.

ABSTRACT: Replacement of phenylalanine with leucine at position 391 in squalene epoxidase was identified as being responsible for terbinafine resistance in mutants of Aspergillus nidulans. The equivalent mutation was engineered into the ergA gene of Aspergillus fumigatus, resulting in an F389L substitution that also conferred resistance to this pathogenic mold.

SUBMITTER: Rocha EM

PROVIDER: S-EPMC1489775 | biostudies-literature | 2006 Jul

REPOSITORIES: biostudies-literature

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A Phe389Leu substitution in ergA confers terbinafine resistance in Aspergillus fumigatus.

Rocha E M F EM Gardiner R E RE Park S S Martinez-Rossi N M NM Perlin D S DS

Antimicrobial agents and chemotherapy 20060701 7

Replacement of phenylalanine with leucine at position 391 in squalene epoxidase was identified as being responsible for terbinafine resistance in mutants of Aspergillus nidulans. The equivalent mutation was engineered into the ergA gene of Aspergillus fumigatus, resulting in an F389L substitution that also conferred resistance to this pathogenic mold. ...[more]

PMID: 16801438

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