Ontology highlight
ABSTRACT:
SUBMITTER: Tsunenari T
PROVIDER: S-EPMC2151534 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Tsunenari Takashi T Nathans Jeremy J Yau King-Wai KW
The Journal of general physiology 20060515 6
Bestrophins are a newly discovered family of Cl(-) channels, some members of which are activated by intracellular Ca(2+). So far, all studies were carried out with whole-cell recordings from plasmid-transfected cultured cells, so it is unclear whether Ca(2+) activates bestrophin through a metabolic mechanism or in a more direct way. We report here experiments that addressed this question with excised, inside-out membrane patches. We chose human bestrophin-4 (hBest4) for heterologous expression b ...[more]