Ontology highlight
ABSTRACT:
SUBMITTER: Barro Soria R
PROVIDER: S-EPMC2785573 | biostudies-literature | 2009 Oct
REPOSITORIES: biostudies-literature
Barro Soria René R Spitzner Melanie M Schreiber Rainer R Kunzelmann Karl K
The Journal of biological chemistry 20060926 43
Epithelial cells express calcium-activated Cl(-) channels of unknown molecular identity. These Cl(-) channels play a central role in diseases such as secretory diarrhea, polycystic kidney disease, and cystic fibrosis. The family of bestrophins has been suggested to form calcium-activated Cl(-) channels. Here, we demonstrate molecular and functional expression of bestrophin-1 (BEST1) in mouse and human airways, colon, and kidney. Endogenous calcium-activated whole cell Cl(-) currents coincide wit ...[more]