Ontology highlight
ABSTRACT:
SUBMITTER: Lengner CJ
PROVIDER: S-EPMC2151746 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Cell stem cell 20071001 4
The Pou domain containing transcription factor Oct4 is a well-established regulator of pluripotency in the inner cell mass of the mammalian blastocyst as well as in embryonic stem cells. While it has been shown that the Oct4 gene is inactivated through a series of epigenetic modifications following implantation, recent studies have detected Oct4 activity in a variety of somatic stem cells and tumor cells. Based on these observations it has been suggested that Oct4 may also function in maintainin ...[more]