Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez DR
PROVIDER: S-EPMC2154479 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Gonzalez Daniel R DR Beigi Farideh F Treuer Adriana V AV Hare Joshua M JM
Proceedings of the National Academy of Sciences of the United States of America 20071212 51
Altered Ca(2+) homeostasis is a salient feature of heart disease, where the calcium release channel ryanodine receptor (RyR) plays a major role. Accumulating data support the notion that neuronal nitric oxide synthase (NOS1) regulates the cardiac RyR via S-nitrosylation. We tested the hypothesis that NOS1 deficiency impairs RyR S-nitrosylation, leading to altered Ca(2+) homeostasis. Diastolic Ca(2+) levels are elevated in NOS1(-/-) and NOS1/NOS3(-/-) but not NOS3(-/-) myocytes compared with wild ...[more]