Functional characterization of Pneumocystis carinii brl1 by transspecies complementation analysis.
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ABSTRACT:
SUBMITTER: Lo Presti L
PROVIDER: S-EPMC2168235 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Publications
Functional characterization of Pneumocystis carinii brl1 by transspecies complementation analysis.
Lo Presti Libera L Cockell Moira M Cerutti Lorenzo L Simanis Viesturs V Hauser Philippe M PM
Eukaryotic cell 20071109 12
Pneumocystis jirovecii is a fungus which causes severe opportunistic infections in immunocompromised humans. The brl1 gene of P. carinii infecting rats was identified and characterized by using bioinformatics in conjunction with functional complementation in Saccharomyces cerevisiae and Schizosaccharomyces pombe. The ectopic expression of this gene rescues null alleles of essential nuclear membrane proteins of the Brr6/Brl1 family in both yeasts. ...[more]
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