Ontology highlight
ABSTRACT:
SUBMITTER: Fu Z
PROVIDER: S-EPMC2168618 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Fu Zhibiao Z Donegan Niles P NP Memmi Guido G Cheung Ambrose L AL
Journal of bacteriology 20071012 24
The mazEF homologs of Staphylococcus aureus, designated mazEF(sa), have been shown to cotranscribe with the sigB operon under stress conditions. In this study, we showed that MazEF(Sa), as with their Escherichia coli counterparts, compose a toxin-antitoxin module wherein MazF(Sa) leads to rapid cell growth arrest and loss in viable CFU upon overexpression. MazF(Sa) is a novel sequence-specific endoribonuclease which cleaves mRNA to inhibit protein synthesis. Using ctpA mRNA as the model substrat ...[more]