Ontology highlight
ABSTRACT:
SUBMITTER: Huntzinger E
PROVIDER: S-EPMC549626 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Huntzinger Eric E Boisset Sandrine S Saveanu Cosmin C Benito Yvonne Y Geissmann Thomas T Namane Abdelkader A Lina Gérard G Etienne Jerome J Ehresmann Bernard B Ehresmann Chantal C Jacquier Alain A Vandenesch François F Romby Pascale P
The EMBO journal 20050127 4
Staphylococcus aureus RNAIII is one of the largest regulatory RNAs, which controls several virulence genes encoding exoproteins and cell-wall-associated proteins. One of the RNAIII effects is the repression of spa gene (coding for the surface protein A) expression. Here, we show that spa repression occurs not only at the transcriptional level but also by RNAIII-mediated inhibition of translation and degradation of the stable spa mRNA by the double-strand-specific endoribonuclease III (RNase III) ...[more]