Antiretroviral activity and Vif sensitivity of rhesus macaque APOBEC3 proteins.
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ABSTRACT:
SUBMITTER: Virgen CA
PROVIDER: S-EPMC2168863 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Publications
Antiretroviral activity and Vif sensitivity of rhesus macaque APOBEC3 proteins.
Virgen Cesar A CA Hatziioannou Theodora T
Journal of virology 20071017 24
The inability of human immunodeficiency virus type 1(HIV-1) to replicate in rhesus macaque cells is in part due to the failure of HIV-1 Vif to counteract the restriction factor APOBEC3G. However, in this study we demonstrate that several rhesus macaque APOBEC3 (rhAPOBEC3) proteins are capable of inhibiting HIV-1 infectivity. There was considerable variation in the ability of a panel of Vif proteins to induce degradation of rhAPOBEC3 proteins, and mutations within HIV-1 Vif that render it capable ...[more]
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