Ontology highlight
ABSTRACT:
SUBMITTER: Zhang A
PROVIDER: S-EPMC3208790 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Zhang Ao A Bogerd Hal H Villinger Francois F Das Gupta Jaydip J Dong Beihua B Klein Eric A EA Hackett John J Schochetman Gerald G Cullen Bryan R BR Silverman Robert H RH
Virology 20111006 1
The gammaretrovirus, xenotropic murine leukemia virus-related virus (XMRV), replicates to high titers in some human cell lines and is able to infect non-human primates. To determine whether APOBEC3 (A3) proteins restrict XMRV infections in a non-human primate model, we sequenced proviral DNA from peripheral blood mononuclear cells of XMRV-infected rhesus macaques. Hypermutation characteristic of A3DE, A3F and A3G activities was observed in the XMRV proviral sequences in vivo. Furthermore, expres ...[more]