Ontology highlight
ABSTRACT:
SUBMITTER: Dang W
PROVIDER: S-EPMC2169183 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Dang Weiwei W Bartholomew Blaine B
Molecular and cellular biology 20071001 23
ATP-dependent chromatin remodeling has an important role in the regulation of cellular differentiation and development. For the first time, a topological view of one of these complexes has been revealed, by mapping the interactions of the catalytic subunit Isw2 with nucleosomal and extranucleosomal DNA in the complex with all four subunits of ISW2 bound to nucleosomes. Different domains of Isw2 were shown to interact with the nucleosome near the dyad axis, another near the entry site of the nucl ...[more]