Ontology highlight
ABSTRACT:
SUBMITTER: Hota SK
PROVIDER: S-EPMC3565048 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Hota Swetansu K SK Bhardwaj Saurabh K SK Deindl Sebastian S Lin Yuan-chi YC Zhuang Xiaowei X Bartholomew Blaine B
Nature structural & molecular biology 20130120 2
The ISWI family of ATP-dependent chromatin remodelers represses transcription by changing nucleosome positions. ISWI regulates nucleosome positioning by requiring a minimal length of extranucleosomal DNA for moving nucleosomes. ISW2 from Saccharomyces cerevisiae, a member of the ISWI family, has a conserved domain called SLIDE (SANT-like ISWI domain) that binds to extranucleosomal DNA ~19 base pairs from the edge of nucleosomes. Loss of SLIDE binding does not perturb binding of the ATPase domain ...[more]