Ontology highlight
ABSTRACT:
SUBMITTER: Insel PA
PROVIDER: S-EPMC2169201 | biostudies-literature | 2007 Apr
REPOSITORIES: biostudies-literature
Biochimica et biophysica acta 20061005 4
By virtue of their large number, widespread distribution and important roles in cell physiology and biochemistry, G-protein-coupled receptors (GPCR) play multiple important roles in clinical medicine. Here, we focus on 3 areas that subsume much of the recent work in this aspect of GPCR biology: (1) monogenic diseases of GPCR; (2) genetic variants of GPCR; and (3) clinically useful pharmacological agonists and antagonists of GPCR. Diseases involving mutations of GPCR are rare, occurring in <1/100 ...[more]