Ontology highlight
ABSTRACT:
SUBMITTER: Kang TH
PROVIDER: S-EPMC2169395 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Kang Tae-Hong TH Park Do-Young DY Choi Yoon Ha YH Kim Kyung-Jin KJ Yoon Ho Sup HS Kim Kyong-Tai KT
Molecular and cellular biology 20071015 24
Mitotic chromatin condensation is essential for cell division in eukaryotes. Posttranslational modification of the N-terminal tail of histone proteins, particularly by phosphorylation by mitotic histone kinases, may facilitate this process. In mammals, aurora B is believed to be the mitotic histone H3 Ser10 kinase; however, it is not sufficient to phosphorylate H3 Ser10 with aurora B alone. We show that histone H3 is phosphorylated by vaccinia-related kinase 1 (VRK1). Direct phosphorylation of T ...[more]