Ontology highlight
ABSTRACT:
SUBMITTER: Jeong MW
PROVIDER: S-EPMC3564537 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Jeong Min-Woo MW Kang Tae-Hong TH Kim Wanil W Choi Yoon Ha YH Kim Kyong-Tai KT
Molecular biology of the cell 20121205 3
Mitogen-activated protein kinase phosphatase 2 (MKP2) is a member of the dual-specificity MKPs that regulate MAP kinase signaling. However, MKP2 functions are still largely unknown. In this study, we showed that MKP2 could regulate histone H3 phosphorylation under oxidative stress conditions. We found that MKP2 inhibited histone H3 phosphorylation by suppressing vaccinia-related kinase 1 (VRK1) activity. Moreover, this regulation was dependent on the selective interaction with VRK1, regardless o ...[more]