Ontology highlight
ABSTRACT:
SUBMITTER: Capkova K
PROVIDER: S-EPMC2170532 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Capková Katerina K Yoneda Yoshiyuki Y Dickerson Tobin J TJ Janda Kim D KD
Bioorganic & medicinal chemistry letters 20071009 23
Botulinum neurotoxins are the most toxic proteins currently known. Based on a recently identified potent lead structure, 2,4-dichlorocinnamic acid hydroxamate, herein we report on the structure-activity relationship of a series of hydroxamate BoNT/A inhibitors. Among them, 2-bromo-4-chlorocinnamic acid hydroxamate, 2-methyl-4-chlorocinnamic acid hydroxamate, and 2-trifluoromethyl-4-chlorocinnamic acid hydroxamate displayed comparable inhibitory activity to that of the lead structure. ...[more]