Ontology highlight
ABSTRACT:
SUBMITTER: Silhar P
PROVIDER: S-EPMC2832098 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Silhár Peter P Capková Katerina K Salzameda Nicholas T NT Barbieri Joseph T JT Hixon Mark S MS Janda Kim D KD
Journal of the American Chemical Society 20100301 9
A new mechanistic class of BoNT/A zinc metalloprotease inhibitors, from Echinacea, exemplified by the natural product d-chicoric acid (I1) is disclosed. A detailed evaluation of chicoric acid's mechanism of inhibition reveals that the inhibitor binds to an exosite, displays noncompetitive partial inhibition, and is synergistic with a competitive active site inhibitor when used in combination. Other components found in Echinacea, I3 and I4, were also inhibitors of the protease. ...[more]