Ontology highlight
ABSTRACT:
SUBMITTER: Ishibashi J
PROVIDER: S-EPMC2171269 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Ishibashi Jeff J Perry Robert L RL Asakura Atsushi A Rudnicki Michael A MA
The Journal of cell biology 20051101 3
MyoD and Myf5 are basic helix-loop-helix transcription factors that play key but redundant roles in specifying myogenic progenitors during embryogenesis. However, there are functional differences between the two transcription factors that impact myoblast proliferation and differentiation. Target gene activation could be one such difference. We have used microarray and polymerase chain reaction approaches to measure the induction of muscle gene expression by MyoD and Myf5 in an in vitro model. In ...[more]