Ontology highlight
ABSTRACT:
SUBMITTER: Testa S
PROVIDER: S-EPMC5964432 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Oxidative medicine and cellular longevity 20180507
The presence of tetraplex structures in the promoter region of the myogenic differentiation 1 gene (MyoD1) was investigated with a specific tetraplex-binding porphyrin (TMPyP4), to test its influence on the expression of MyoD1 itself and downstream-regulated genes during myogenic differentiation. TMPyP4-exposed C2C12 myoblasts, blocking MyoD1 transcription, proliferated reaching confluence and fused forming elongated structures, resembling myotubes, devoid of myosin heavy chain 3 (MHC) expressio ...[more]