Ontology highlight
ABSTRACT:
SUBMITTER: Lynch J
PROVIDER: S-EPMC2171392 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Lynch Jeffrey J Guo Lei L Gelebart Pascal P Chilibeck Kaari K Xu Jian J Molkentin Jeffery D JD Agellon Luis B LB Michalak Marek M
The Journal of cell biology 20050701 1
We uncovered a new pathway of interplay between calreticulin and myocyte-enhancer factor (MEF) 2C, a cardiac-specific transcription factor. We establish that calreticulin works upstream of calcineurin and MEF2C in a Ca(2+)-dependent signal transduction cascade that links the endoplasmic reticulum and the nucleus during cardiac development. In the absence of calreticulin, translocation of MEF2C to the nucleus is compromised. This defect is reversed by calreticulin itself or by a constitutively ac ...[more]