Ontology highlight
ABSTRACT:
SUBMITTER: Etienne-Manneville S
PROVIDER: S-EPMC2171429 | biostudies-literature | 2005 Sep
REPOSITORIES: biostudies-literature
Etienne-Manneville Sandrine S Manneville Jean-Baptiste JB Nicholls Sarah S Ferenczi Michael A MA Hall Alan A
The Journal of cell biology 20050901 6
Cell polarization is essential in a wide range of biological processes such as morphogenesis, asymmetric division, and directed migration. In this study, we show that two tumor suppressor proteins, adenomatous polyposis coli (APC) and Dlg1-SAP97, are required for the polarization of migrating astrocytes. Activation of the Par6-PKCzeta complex by Cdc42 at the leading edge of migrating cells promotes both the localized association of APC with microtubule plus ends and the assembly of Dlg-containin ...[more]