Ontology highlight
ABSTRACT:
SUBMITTER: Lin F
PROVIDER: S-EPMC2171618 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
Lin Fang F Sepich Diane S DS Chen Songhai S Topczewski Jacek J Yin Chunyue C Solnica-Krezel Lilianna L Hamm Heidi H
The Journal of cell biology 20050531 5
Galpha(12/13) have been implicated in numerous cellular processes, however, their roles in vertebrate gastrulation are largely unknown. Here, we show that during zebrafish gastrulation, suppression of both Galpha(12) and Galpha(13) signaling by overexpressing dominant negative proteins and application of antisense morpholino-modified oligonucleotide translation interference disrupted convergence and extension without changing embryonic patterning. Analyses of mesodermal cell behaviors revealed t ...[more]