Ontology highlight
ABSTRACT:
SUBMITTER: Williams ML
PROVIDER: S-EPMC7250581 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Williams Margot Lk ML Solnica-Krezel Lilianna L
eLife 20200422
During vertebrate gastrulation, convergence and extension (C and E) of the primary anteroposterior (AP) embryonic axis is driven by polarized mediolateral (ML) cell intercalations and is influenced by AP axial patterning. Nodal signaling is essential for patterning of the AP axis while planar cell polarity (PCP) signaling polarizes cells with respect to this axis, but how these two signaling systems interact during C and E is unclear. We find that the neuroectoderm of Nodal-deficient zebrafish g ...[more]