A small surface hydrophobic stripe in the coiled-coil domain of type I keratins mediates tetramer stability.
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ABSTRACT:
SUBMITTER: Bernot KM
PROVIDER: S-EPMC2171788 | biostudies-literature | 2005 Mar
REPOSITORIES: biostudies-literature
Publications
A small surface hydrophobic stripe in the coiled-coil domain of type I keratins mediates tetramer stability.
Bernot Kelsie M KM Lee Chang-Hun CH Coulombe Pierre A PA
The Journal of cell biology 20050301 6
Intermediate filaments (IFs) are fibrous polymers encoded by a large family of differentially expressed genes that provide crucial structural support in the cytoplasm and nucleus in higher eukaryotes. The mechanisms involved in bringing together approximately 16 elongated coiled-coil dimers to form an IF are poorly defined. Available evidence suggests that tetramer subunits play a key role during IF assembly and regulation. Through molecular modeling and site-directed mutagenesis, we document a ...[more]
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