Ontology highlight
ABSTRACT:
SUBMITTER: Culjkovic B
PROVIDER: S-EPMC2171863 | biostudies-literature | 2005 Apr
REPOSITORIES: biostudies-literature
Culjkovic Biljana B Topisirovic Ivan I Skrabanek Lucy L Ruiz-Gutierrez Melisa M Borden Katherine L B KL
The Journal of cell biology 20050418 2
The eukaryotic translation initiation factor eIF4E is a critical modulator of cellular growth with functions in the nucleus and cytoplasm. In the cytoplasm, recognition of the 5' m(7)G cap moiety on all mRNAs is sufficient for their functional interaction with eIF4E. In contrast, we have shown that in the nucleus eIF4E associates and promotes the nuclear export of cyclin D1, but not GAPDH or actin mRNAs. We determined that the basis of this discriminatory interaction is an approximately 100-nt s ...[more]