Ontology highlight
ABSTRACT:
SUBMITTER: Chi B
PROVIDER: S-EPMC4066777 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Chi Binkai B Wang Ke K Du Yanhua Y Gui Bin B Chang Xingya X Wang Lantian L Fan Jing J Chen She S Wu Xudong X Li Guohui G Cheng Hong H
Nucleic acids research 20140429 11
Viral RNA elements that facilitate mRNA export are useful tools for identifying cellular RNA export factors. Here we show that hepatitis B virus post-transcriptional element (PRE) is one such element, and using PRE several new cellular mRNA export factors were identified. We found that PRE drastically enhances the cytoplasmic accumulation of cDNA transcripts independent of any viral protein. Systematic deletion analysis revealed the existence of a 116 nt functional Sub-Element of PRE (SEP1). The ...[more]