Ontology highlight
ABSTRACT:
SUBMITTER: Sengupta S
PROVIDER: S-EPMC2172115 | biostudies-literature | 2004 Sep
REPOSITORIES: biostudies-literature
Sengupta Sagar S Robles Ana I AI Linke Steven P SP Sinogeeva Natasha I NI Zhang Ran R Pedeux Remy R Ward Irene M IM Celeste Arkady A Nussenzweig André A Chen Junjie J Halazonetis Thanos D TD Harris Curtis C CC
The Journal of cell biology 20040901 6
Bloom's syndrome is a rare autosomal recessive genetic disorder characterized by chromosomal aberrations, genetic instability, and cancer predisposition, all of which may be the result of abnormal signal transduction during DNA damage recognition. Here, we show that BLM is an intermediate responder to stalled DNA replication forks. BLM colocalized and physically interacted with the DNA damage response proteins 53BP1 and H2AX. Although BLM facilitated physical interaction between p53 and 53BP1, 5 ...[more]