A New BRCT Binding Mode in TopBP1-BLM Helicase Interaction.
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ABSTRACT:
SUBMITTER: Mer G
PROVIDER: S-EPMC5642270 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
A New BRCT Binding Mode in TopBP1-BLM Helicase Interaction.
Mer Georges G Botuyan Maria Victoria MV
Structure (London, England : 1993) 20171003 10
Tandem BRCT domains are phophoprotein binding modules. In this issue of Structure, Sun et al. (2017) show that a single BRCT domain in TopBP1 binds tightly and specifically to phosphorylated Bloom syndrome helicase (BLM). This work reveals a novel BRCT binding mode and suggests a similar mechanism for TopBP1 interaction with 53BP1. ...[more]
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