Ontology highlight
ABSTRACT:
SUBMITTER: Woodring PJ
PROVIDER: S-EPMC2173320 | biostudies-literature | 2002 Mar
REPOSITORIES: biostudies-literature
Woodring Pamela J PJ Litwack E David ED O'Leary Dennis D M DD Lucero Ginger R GR Wang Jean Y J JY Hunter Tony T
The Journal of cell biology 20020225 5
The nonreceptor tyrosine kinase encoded by the c-Abl gene has the unique feature of an F-actin binding domain (FABD). Purified c-Abl tyrosine kinase is inhibited by F-actin, and this inhibition can be relieved through mutation of its FABD. The c-Abl kinase is activated by physiological signals that also regulate the actin cytoskeleton. We show here that c-Abl stimulated the formation of actin microspikes in fibroblasts spreading on fibronectin. This function of c-Abl is dependent on kinase activ ...[more]