Ontology highlight
ABSTRACT:
SUBMITTER: Silberman I
PROVIDER: S-EPMC3407662 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Silberman Isabelle I Sionov Ronit Vogt RV Zuckerman Valentina V Haupt Sue S Goldberg Zehavit Z Strasser Andreas A Ben-Sasson Zami S ZS Baniyash Michal M Koleske Anthony J AJ Haupt Ygal Y
Cell cycle (Georgetown, Tex.) 20081223 24
C-Abl (Abl) regulates multiple cellular processes, including proliferation, survival, shape determination and motility, and participates in cellular responses to genotoxic and oxidative stress stimuli. Mice lacking Abl exhibit retarded growth, osteoporosis and defects in the immune system resulting in lymphopoenia and susceptibility to infections, leading to early death. To define the role of Abl in the regulation of adult T cells we ablated Abl exclusively in T cells by generating mice with flo ...[more]