Ontology highlight
ABSTRACT:
SUBMITTER: Debnath J
PROVIDER: S-EPMC2173511 | biostudies-literature | 2003 Oct
REPOSITORIES: biostudies-literature
Debnath Jayanta J Walker Stephanie J SJ Brugge Joan S JS
The Journal of cell biology 20031020 2
Activation of the serine/threonine kinase Akt/PKB positively impacts on three cellular processes relevant to tumor progression: proliferation, survival, and cell size/growth. Using a three-dimensional culture model of MCF-10A mammary cells, we have examined how Akt influences the morphogenesis of polarized epithelial structures. Activation of a conditionally active variant of Akt elicits large, misshapen structures, which primarily arise from the combined effects of Akt on proliferation and cell ...[more]