Ontology highlight
ABSTRACT:
SUBMITTER: Russell CJ
PROVIDER: S-EPMC2173521 | biostudies-literature | 2003 Oct
REPOSITORIES: biostudies-literature
The Journal of cell biology 20031001 2
Many viral fusion-mediating glycoproteins couple alpha-helical bundle formation to membrane merger, but have different methods for fusion activation. To study paramyxovirus-mediated fusion, we mutated the SV5 fusion (F) protein at conserved residues L447 and I449, which are adjacent to heptad repeat (HR) B and bind to a prominent cavity in the HRA trimeric coiled coil in the fusogenic six-helix bundle (6HB) structure. These analyses on residues L447 and I449, both in intact F protein and in 6HB, ...[more]