Ontology highlight
ABSTRACT:
SUBMITTER: Sakaguchi M
PROVIDER: S-EPMC2173690 | biostudies-literature | 2003 Nov
REPOSITORIES: biostudies-literature
Sakaguchi Masakiyo M Miyazaki Masahiro M Takaishi Mikiro M Sakaguchi Yoshihiko Y Makino Eiichi E Kataoka Noriyuki N Yamada Hidenori H Namba Masayoshi M Huh Nam-ho NH
The Journal of cell biology 20031117 4
An increase in extracellular Ca2+ induces growth arrest and differentiation of human keratinocytes in culture. We examined possible involvement of S100C/A11 in this growth regulation. On exposure of the cells to high Ca2+, S100C/A11 was specifically phosphorylated at 10Thr and 94Ser. Phosphorylation facilitated the binding of S100C/A11 to nucleolin, resulting in nuclear translocation of S100C/A11. In nuclei, S100C/A11 liberated Sp1/3 from nucleolin. The resulting free Sp1/3 transcriptionally act ...[more]