Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki D
PROVIDER: S-EPMC5568930 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Suzuki Daisuke D Pinto Filipa F Senoo Makoto M
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20170516 3
Cultured epidermal autografts have been used worldwide since 1981 for patients with extensive third-degree burn wounds and limited skin donor sites. Despite significant progress in techniques toward improving clinical outcome of skin grafts, the long in vitro preparation time of cultured autografts has remained a major factor limiting its widespread use. Here, we show that pharmacological inhibition of TGF-β signaling promotes the expansion of human epidermal keratinocytes (HEKs) with high proli ...[more]