Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi N
PROVIDER: S-EPMC2174204 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Takahashi Nobuyuki N Li Feng F Hua Kunjie K Deng Jianbei J Wang Chih-Hong CH Bowers Robert R RR Bartness Timothy J TJ Kim Hyung-Suk HS Harp Joyce B JB
Cell metabolism 20071201 6
An overactive renin-angiotensin system is associated with obesity and the metabolic syndrome. However, the mechanisms behind it are unclear. Cleaving angiotensinogen to angiotensin I by renin is a rate-limiting step of angiotensin II production, but renin is suggested to have angiotensin-independent effects. We generated mice lacking renin (Ren1c) using embryonic stem cells from C57BL/6 mice, a strain prone to diet-induced obesity. Ren1c(-/-) mice are lean, insulin sensitive, and resistant to di ...[more]