Ontology highlight
ABSTRACT:
SUBMITTER: Xie X
PROVIDER: S-EPMC6507421 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Xie Xiangyang X Yang Haili H An Juan Ji JJ Houtz Jessica J Tan Ji-Wei JW Xu Haifei H Liao Guey-Ying GY Xu Zhi-Xiang ZX Xu Baoji B
Cell metabolism 20190117 4
Anxiety disorders are associated with body weight changes in humans. However, the mechanisms underlying anxiety-induced weight changes remain poorly understood. Using Emx1<sup>Cre/+</sup> mice, we deleted the gene for brain-derived neurotrophic factor (BDNF) in the cortex, hippocampus, and some amygdalar subregions. The resulting mutant mice displayed impaired GABAergic transmission and elevated anxiety. They were leaner when fed either a chow diet or a high-fat diet, owing to higher sympathetic ...[more]