Ontology highlight
ABSTRACT:
SUBMITTER: Capili AD
PROVIDER: S-EPMC2174906 | biostudies-literature | 2007 Dec
REPOSITORIES: biostudies-literature
Capili Allan D AD Lima Christopher D CD
Current opinion in structural biology 20071004 6
Ubiquitin (Ub) and ubiquitin-like (Ubl) proteins regulate a diverse array of cellular pathways through post-translational attachment to protein substrates. Ub/Ubl-mediated signaling is initiated through E1, E2, and E3-mediated conjugation, transduced by proteins that recognize Ub/Ubl-modified substrates, and terminated by proteases which remove the Ub/Ubl from the substrate. Recent structural studies have elucidated mechanisms pertinent to Ub/Ubl conjugation, recognition, and deconjugation, high ...[more]