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Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways.

ABSTRACT: Ubiquitin (Ub) and ubiquitin-like (Ubl) proteins regulate a diverse array of cellular pathways through post-translational attachment to protein substrates. Ub/Ubl-mediated signaling is initiated through E1, E2, and E3-mediated conjugation, transduced by proteins that recognize Ub/Ubl-modified substrates, and terminated by proteases which remove the Ub/Ubl from the substrate. Recent structural studies have elucidated mechanisms pertinent to Ub/Ubl conjugation, recognition, and deconjugation, highlighting essential steps during Ub/Ubl modification that illustrate common and divergent mechanistic themes within this important process.

SUBMITTER: Capili AD

PROVIDER: S-EPMC2174906 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature

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Taking it step by step: mechanistic insights from structural studies of ubiquitin/ubiquitin-like protein modification pathways.

Capili Allan D AD Lima Christopher D CD

Current opinion in structural biology 20071004 6

Ubiquitin (Ub) and ubiquitin-like (Ubl) proteins regulate a diverse array of cellular pathways through post-translational attachment to protein substrates. Ub/Ubl-mediated signaling is initiated through E1, E2, and E3-mediated conjugation, transduced by proteins that recognize Ub/Ubl-modified substrates, and terminated by proteases which remove the Ub/Ubl from the substrate. Recent structural studies have elucidated mechanisms pertinent to Ub/Ubl conjugation, recognition, and deconjugation, high ...[more]

PMID: 17919899

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