Ontology highlight
ABSTRACT:
SUBMITTER: Ungermannova D
PROVIDER: S-EPMC3339042 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Ungermannova Dana D Parker Seth J SJ Nasveschuk Christopher G CG Chapnick Douglas A DA Phillips Andrew J AJ Kuchta Robert D RD Liu Xuedong X
Journal of biomolecular screening 20120124 4
Protein degradation via the ubiquitin-proteasome pathway is important for a diverse number of cellular processes ranging from cell signaling to development. Disruption of the ubiquitin pathway occurs in a variety of human diseases, including several cancers and neurological disorders. Excessive proteolysis of tumor suppressor proteins, such as p27, occurs in numerous aggressive human tumors. To discover small-molecule inhibitors that potentially prevent p27 degradation, we developed a series of ...[more]