Ontology highlight
ABSTRACT:
SUBMITTER: Hirst J
PROVIDER: S-EPMC2175106 | biostudies-literature | 2000 Apr
REPOSITORIES: biostudies-literature
Hirst J J Lui W W WW Bright N A NA Totty N N Seaman M N MN Robinson M S MS
The Journal of cell biology 20000401 1
We have cloned and characterized members of a novel family of proteins, the GGAs. These proteins contain an NH(2)-terminal VHS domain, one or two coiled-coil domains, and a COOH-terminal domain homologous to the COOH-terminal "ear" domain of gamma-adaptin. However, unlike gamma-adaptin, the GGAs are not associated with clathrin-coated vesicles or with any of the components of the AP-1 complex. GGA1 and GGA2 are also not associated with each other, although they colocalize on perinuclear membrane ...[more]