Ontology highlight
ABSTRACT:
SUBMITTER: Harris TW
PROVIDER: S-EPMC2175188 | biostudies-literature | 2000 Aug
REPOSITORIES: biostudies-literature
Harris T W TW Hartwieg E E Horvitz H R HR Jorgensen E M EM
The Journal of cell biology 20000801 3
Synaptojanin is a polyphosphoinositide phosphatase that is found at synapses and binds to proteins implicated in endocytosis. For these reasons, it has been proposed that synaptojanin is involved in the recycling of synaptic vesicles. Here, we demonstrate that the unc-26 gene encodes the Caenorhabditis elegans ortholog of synaptojanin. unc-26 mutants exhibit defects in vesicle trafficking in several tissues, but most defects are found at synaptic termini. Specifically, we observed defects in the ...[more]