Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC5356223 | biostudies-literature | 2017 Jan-Feb
REPOSITORIES: biostudies-literature
eNeuro 20170101 1
Membrane trafficking pathways must be exquisitely coordinated at synaptic terminals to maintain functionality, particularly during conditions of high activity. We have generated null mutations in the <i>Drosophila</i> homolog of pallidin, a central subunit of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), to determine its role in synaptic development and physiology. We find that Pallidin localizes to presynaptic microtubules and cytoskeletal structures, and that the stability ...[more]