Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Marcos A
PROVIDER: S-EPMC2175356 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
García-Marcos Alberto A Morreale Antonio A Guarinos Esther E Briones Elisa E Remacha Miguel M Ortiz Angel R AR Ballesta Juan P G JP
Nucleic acids research 20071016 21
Eukaryotic ribosomal stalk protein L12 and its bacterial orthologue L11 play a central role on ribosomal conformational changes during translocation. Deletion of the two genes encoding L12 in Saccharomyces cerevisiae resulted in a very slow-growth phenotype. Gene RPL12B, but not the RPL12A, cloned in centromeric plasmids fully restored control protein level and the growth rate when expressed in a L12-deprived strain. The same strain has been transformed to express Escherichia coli protein EcL11 ...[more]