Evidence that dynamin-2 functions as a signal-transducing GTPase.
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ABSTRACT:
SUBMITTER: Fish KN
PROVIDER: S-EPMC2185575 | biostudies-literature | 2000 Jul
REPOSITORIES: biostudies-literature
Publications
Evidence that dynamin-2 functions as a signal-transducing GTPase.
Fish K N KN Schmid S L SL Damke H H
The Journal of cell biology 20000701 1
The role of dynamin GTPases in the regulation of receptor-mediated endocytosis is well established. Here, we present new evidence that the ubiquitously expressed isoform dynamin-2 (dyn2) can also function in a signal transduction pathway(s). A </=5-fold increase of dyn2 relative to endogenous levels activates the transcription factor p53 and induces apoptosis, as demonstrated by reduced cell proliferation, DNA fragmentation, and caspase-3 activation. Dyn2-triggered apoptosis occurs only in divid ...[more]
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