Ontology highlight
ABSTRACT:
SUBMITTER: Gherardi E
PROVIDER: S-EPMC218709 | biostudies-literature | 2003 Oct
REPOSITORIES: biostudies-literature
Gherardi Ermanno E Youles Mark E ME Miguel Ricardo N RN Blundell Tom L TL Iamele Luisa L Gough Julian J Bandyopadhyay Abhishek A Hartmann Guido G Butler P Jonathan G PJ
Proceedings of the National Academy of Sciences of the United States of America 20031003 21
Little is known about the large ectodomain of MET, the product of the c-met protooncogene and receptor for hepatocyte growth factor/scatter factor (HGF/SF). Here, we establish by deletion mutagenesis that the HGF/SF and heparin-binding sites of MET are contained within a large N-terminal domain spanning the alpha-chain (amino acids 25-307) and the first 212 amino acids of the beta-chain (amino acids 308-519). Neither the cystine-rich domain (amino acids 520-561) nor the C-terminal half of MET (a ...[more]