Ontology highlight
ABSTRACT:
SUBMITTER: Gherardi E
PROVIDER: S-EPMC1449643 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Gherardi Ermanno E Sandin Sara S Petoukhov Maxim V MV Finch John J Youles Mark E ME Ofverstedt Lars-Göran LG Miguel Ricardo N RN Blundell Tom L TL Vande Woude George F GF Skoglund Ulf U Svergun Dmitri I DI
Proceedings of the National Academy of Sciences of the United States of America 20060306 11
The polypeptide growth factor, hepatocyte growth factor/scatter factor (HGF/SF), shares the multidomain structure and proteolytic mechanism of activation of plasminogen and other complex serine proteinases. HGF/SF, however, has no enzymatic activity. Instead, it controls the growth, morphogenesis, or migration of epithelial, endothelial, and muscle progenitor cells through the receptor tyrosine kinase MET. Using small-angle x-ray scattering and cryo-electron microscopy, we show that conversion o ...[more]